华西口腔医学杂志2011，Vol.29Issue(1)：17-20,26,5.DOI:10.3969/j.issn.1000-1182.2011.01.005
正畸微种植体周围炎对骨结合界面影响的研究
Influence of the peri-implantitis to the microscrew-bone interface
摘要
Abstract
Objective To study the histological change of microscrew-bone interface, detect the relative cytokine of gingival crevicular fluid, and explore the impossible mechanism of peri-implantitis. Methods Four male Beagles were collected. Randomly select one side of animals jaw as the experimental group to induce the peri-implantitis,and another side as the controll group. Four microscrews were implanted on each side. In the 1st, 2nd, 3rd, 4th weeks after implantation, collect peri-implant sulcular fluid(PISF) and detect tumor necrosis factor-α (TNF-α) levels before sacrificed, and the harvest tissue were observed in histological ways. Results According to the extension of time after implantation, the experimental group showed visible progress of interface destruction: 1st week after implantation showed large numbers inflammatory cells collected at the neck but did not undermine the cortical bone; 2nd week after implantation, cortical bone were observed angular absorption; Bone resorption continued to develop and at the 4th week, bone resorption were enlarged to the second thread of microscrew and the interface was filled with a large number of collagen fibers. Conclusion The destruction of interface began at the neck of microscrew, and the further development was along the interface in depth.Both microscrews with peri-implantitis and the healthy controls showed the presence of TNF-α. Inflammation accumulation might trigger the up-regulation of TNF-α level, and the onset of inflammation would enhance the up-trend.关键词
微种植体/微种植体周围炎/肿瘤坏死因子-α/种植体周围龈沟液Key words
micrescrew/ peri-implantitis/ tumor necrosis factor-α/ peri-implant sulcular fluid分类
医药卫生引用本文复制引用
胡赟 ,郑雷蕾,唐甜,赵志河,宋锦磷,邓锋..正畸微种植体周围炎对骨结合界面影响的研究[J].华西口腔医学杂志,2011,29(1):17-20,26,5.基金项目
国家自然科学基金资助项目(81000463和10902075) （81000463和10902075）
高等学校博士学科点专项科研基金新教师类基金资助项目(200955031-20006) （200955031-20006）
