基础医学与临床2011，Vol.31Issue(1)：62-67,6.
α-内收蛋白CA60T和血管紧张素原M235T基因多态性与原发性高血压发病风险相关
Association of α-adducin G460T and AGT M235T gene polymorphisms with the risk of essential hypertension
摘要
Abstract
Objective To investigate the association between polymorphism of α-adducin G460T, angiotensinogen (AGT) M235T genes and essential hypertension (EH) of Han nationality. Methods MS-PCR and RFLP-PCR were used to detect the polymorphism of α-adducin G460T, AGT M235T genes in 305 EH patients and 305 agematched, nationality normotensive controls (NT), biochemical index were also detected. Results The G460T polymorphism of α-adducin gene was not significantly associated with EH, the genotype frequencies were 24. 60％, 52. 78％ and 22. 62％ in the patient group and 28. 53％, 48.85％ and 22. 62％ in the control group respectively. G and T allele frequencies were 50. 98％, 49. 02％ in the patient group and 52. 95％, 47.05％ in the control group; The M235T polymorphism of AGT gene was significantly associated with EH, the genotype frequencies were 18. 69％, 52. 46％ and 8. 85％ in the patient group and 9. 51％, 41.64％ and 48.85％ in the control group (P ＜ 0. 01 ), respectively. M and T allele frequencies were 44. 92％, 55.08％ in the patient group and 30. 33％, 69. 67％ in the control group( P ＜ 0. 01 ); There were statistically significant distribution of M235T genotype of AGT and G46OT genotype of α-adducin combined genes with EH except GG genotype of α-adducin; Individuals carrying TT genotype of AGT M235T gene showed high risk of EH (OR =2. 35, 95％CI = 1.69 ～3.28, P ＜0. 01 ). Conclusion The TT genotype of AGT M235T gene may be related with high risk of EH, and G460T polymorphism of α-adducin gene has no relation to incidence of EH in Han nationality.关键词
α-内收蛋白/血管紧张素原/原发性高血压/基因多态性Key words
α-adducin/ angiotensinogen/ essential hypertension/ gene polymorphisms分类
医药卫生引用本文复制引用
钟发德,张莉娜,徐进,张月苗,费丽娟,陈东妮..α-内收蛋白CA60T和血管紧张素原M235T基因多态性与原发性高血压发病风险相关[J].基础医学与临床,2011,31(1):62-67,6.基金项目
宁波农业与社会发展科研攻关项目(2007C10019) （2007C10019）
