基础医学与临床2011,Vol.31Issue(1):97-100,4.
TLR接头蛋白研究进展
Toll-like receptor adaptor proteins
摘要
Abstract
Toll-like receptor (TLR) is a pathogen recognition receptor and is the item of research in recent years.It discriminates different pathogen-associated molecular patterns (PAMPs) and activates signaling cascades leading to immune responses. The specific TLR signal is conducted by adaptor proteins containing toll-interleukinl receptor (TIR) domains. The function is carried out by MYD88 or no-MYD88/TRIF pathway involving five TIR adaptors:MYD88, MAL, TRIF, TRAM and SARM.关键词
TLR/TIR/接头蛋白/信号传导Key words
TLR/ TIR/ adaptor protein/ signal transduction分类
医药卫生引用本文复制引用
董秋萍,李涛,熊自忠..TLR接头蛋白研究进展[J].基础医学与临床,2011,31(1):97-100,4.基金项目
国家自然基金(30801088) (30801088)
安徽省卫生厅临床医学应用技术项目(2008A022) (2008A022)
安徽省高校自然科研基金(KJ2009B078) (KJ2009B078)
教育部科学技术研究重点项目(209059) (209059)
安徽省优秀青年科技基金(08040106815) (08040106815)
安徽省人事厅(2008-25)、卫生厅人才基金(2009332) (2008-25)