神经损伤与功能重建2011，Vol.6Issue(2)：99-102,4.DOI:10.3870/sjsscj.2011.02.005
黄连解毒汤对AD小鼠学习记忆能力的影响
Huang Lian Jie Du Decoction Improves Learning and Memory Ability in Alzheimer's Disease Mice
摘要
Abstract
Objective: To observe the effects of huang lian jie du decoction (HLJDD) on learning and memory of Alzheimer's disease (AD) mice. Methods: Sixty AD mice were randomly divided into groups CMC, aricept, high dose HLJDD, middle dose HLJDD and low dose HLJDD (each group involved 12 mice). Mice were intragastrically treated with 0.5％CMC, 3 mg/kg aricep, 865 mg/kg HLJDD, 433 mg/kg HLJDD and 216 mg/kg HLJDD respectively once a day for consecutive 180 days. Morris water maze test was applied to measure the learning and memory ability. Results: The escape latency and the average swim path of the mice in aricept, high dose HLJDD, and middle dose HLJDD groups but not in low dose HLJDD group were significantly shorter than that in CMC group (P＜0.05). Conclusion: HLJDD improves learning and memory ability in AD mice.关键词
黄连解毒汤/阿尔茨海默病/学习/定位航行Key words
huang lian jie du decoction/ Alzheimer's disease/ learning/ memory分类
医药卫生引用本文复制引用
陈国华,王月古,邱昕,梅瑰..黄连解毒汤对AD小鼠学习记忆能力的影响[J].神经损伤与功能重建,2011,6(2):99-102,4.基金项目
湖北省自然科学基金资助项目(No.2007ABA060) （No.2007ABA060）
