湖南中医药大学学报2011，Vol.31Issue(1)：15-17,29,4.DOI:10.3969/j.issn.1674-070X.2011.01.004.015.03
环磷酰胺复制中老年男性雄激素部分缺乏综合征大鼠模型的研究
Study of partial and rogen deficiency model induced by cyclophosphamide in rats
摘要
Abstract
Objective To reproduce the partial and rogen deficiency model using cyclophosphamide (CP) in rats. Methods 20 rats were divided randomly into normal control group (N) and model group (M). Before modeling and after modeling 1 day and 30 days, all the rats were measured their general situation and weight, observed in tail suspension experiment and exhaustion swimming test and their testicular index, and evaluated their status, serum Tr and FT level were detected with radiation immune measuring, and leydig cell stAR with immunohistochemical. Result Compared with N, the tail suspension test time in M was longer(P＜0.01) and exhaustion swimming time shorter(P＜0.01); the serum Tr and FT level and expression level of leydig cell stAR protein decreased (P＜0.05). Conclusion The serum TT and FT level to decline rats by CP is similar to clinical PADAM.关键词
中老年男性雄激素部分缺乏综合征/环磷酰胺/动物模型/大鼠Key words
partial androgen deficiency of aging male (PADAM)/ cyclophosphamide (CP)/ animal model/ rats分类
医药卫生引用本文复制引用
何清湖,周兴..环磷酰胺复制中老年男性雄激素部分缺乏综合征大鼠模型的研究[J].湖南中医药大学学报,2011,31(1):15-17,29,4.基金项目
国家自然科学基金项目(30973759/H2709) （30973759/H2709）
湖南省自然科学基金项目(09JJ3054). （09JJ3054）
