寄生虫与医学昆虫学报2011，Vol.18Issue(1)：11-14,4.DOI:10.3969/j.issn.1005-0507.2011.01.003
弓形虫速殖子入侵对宿主细胞窖蛋白-1的表达变化
Study on the Change of Caveolin-1 During the Invasion of Toxoplasma gondii
覃珊珊 1汪琦 1朱家勇 1江钢锋 1李娟兰1
作者信息
- 1. 广东药学院基础学院寄生虫学教研室,广州510006
- 折叠
摘要
Abstract
Caveolae is a specific invagination mini-district, and caveolin-1 is a marker protein of caveolae. Our work focus on the expression change of caveolin-1 during the invasive process for the further study on the control and treatment of Toxoplasmosis. Based on gene sequence of caveolin-1 in GenBank, we designed primers for RT-PCR and real-time PCR to detect the changes of the expression of caveolin-1 at 10 min, 30 min and 60 min after invasion of Toxoplasma gondii into the host cells. The results showed that the expression of caveolin-1 was positive correlation with the concentration of the parasites. With the increase of the parasites, the expression of caveolin-1 increased, and also with the increase of infection times, it showed an increasing tendency. It was concluded that caveolin 1 may participate the process of T. gondii initiative invasion.关键词
刚地弓形虫/窖蛋白-1/实时荧光定量PCR引用本文复制引用
覃珊珊,汪琦,朱家勇,江钢锋,李娟兰..弓形虫速殖子入侵对宿主细胞窖蛋白-1的表达变化[J].寄生虫与医学昆虫学报,2011,18(1):11-14,4.
