江西农业大学学报2011，Vol.33Issue(1)：157-161,5.
青钱柳多糖降血脂作用的研究
Studies on Hypolipemic Effect of Cyclocarya paliurus (Batal)Iljinskaja Polysaccharide
摘要
Abstract
The hypolipemic effect of Cyclocarya paliurus (Batal) lljinskaja polysaccharide was study by in vivo and in vtro experments. The hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja polysaccharide was detected in vitro by measuring the activity of pancreatic lipase. A test model of mice was made according to lipid level of the animals. The animals were divided into 7 groups: the group with high dosages( H ) (polysaccharide, 300 mg/kg), the group with medium dosages(M) (polysaccharide, 200 mg/kg), the group with low dosages(L) (polysaccharide, 100 mg/kg ), the group of simvastatin treatment (ST) (3 mg/kg), the group of simvastatin + medium dosages treatment (ST + M) (3 mg/kg + 200 mg/kg) ,the model group with hyperlipidemia, and the normal group. All the mice were fed for 4 weeks. Then the influences of Cyclocarya paliurus (Batal) Iljinskaja polysaccharide on triglycerides ( TG), total cholesterol ( TC ), low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL)of serum in mice were determined every second week. Cyclocarya paliurus (Batal) Iljinskaja polysaccharide could inhibit the activity of pancreatic lipase in vitro. In the animal test, polysaccharide could remarkably reduce the level of serum TC and LDL(P ＜0.01 ), the effect of high dosages was the best, almost as effective as that of the group of sinvastatin treatment. All this suggests that Cyclocarya paliurus (Batal) lljinskaja polysaccharide has good hypolipemic effect.关键词
青钱柳/多糖/高脂血症/降血脂作用分类
农业科技引用本文复制引用
黄明圈,上官新晨,徐明生,王文君,沈勇根,蒋艳,陈琴,陈婷婷..青钱柳多糖降血脂作用的研究[J].江西农业大学学报,2011,33(1):157-161,5.基金项目
国家科技部星火项目(2002EA730001)、江西省科技厅重点项目(2009BGA01900)、江西省自然科学基金 项目(2009GZN0014)和江西省研究生创新基金项目(YC09A067) （2002EA730001）
