山东医药2011，Vol.51Issue(3)：21-23,3.
Ku70蛋白在局部晚期喉癌组织中的表达及与临床病理特征、预后的关系
Expression of Ku70 protein in locally advanced laryngeal carcinoma and its correlation with the clinical pathological features and prognosis
摘要
Abstract
Objective To study the expression of Ku70 protein and its clinical significance in the patients with locally advanced laryngeal carcinoma. Methods The expression of Ku70 protein in 100 patients with locally advanced laryngeal cancer of laryngeal biopsy specimens before treatment were detected by immunohistochemistry. The relationship was analyzed between the Ku70 protein expression and clinical pathological features of tumor, such as the stage, smoking, lymph node metastasis and survival rate and so on. Results The overexpression rate of Ku70 protein was 45％ in locally advanced laryngeal carcinoma tisaue,and its high expression was closely related with the N stage (P ＜0.01 ) ,but not obvious related with T stage, TNM stage, smoking and gender. The 5-year survival rate about 45 cases with overexpression of Ku70 protein and 55 cases with low expression was 37％ ,58％ respectively ( P ＜ 0.05 ). Conclusion There are overexpression of Ku70 protein in locally advanced laryngeal carcinoma, detecting its expression level has an important reference value for the individual treatment, targeted therapy and prognosis prediction.关键词
Ku70蛋白/喉肿瘤,喉癌Key words
Ku70 protein/ laryngeal neoplasms； laryngeal carcinoma分类
医药卫生引用本文复制引用
蒋伟,林静,陆竞艳,唐华英,刘美莲..Ku70蛋白在局部晚期喉癌组织中的表达及与临床病理特征、预后的关系[J].山东医药,2011,51(3):21-23,3.基金项目
广西壮族自治区卫生厅立项课题(合同号Z2008300). （合同号Z2008300）
