山东医药2011，Vol.51Issue(3)：24-25,2.
SLE患者PBMCs细胞凋亡及其相关基因Bax、p53、C-myc蛋白表达的临床意义
Clinical significance of the apoptosis and Bax,p53 ,c-myc protein expression of the PBMCs in systemic lupus erythematosus patients
摘要
Abstract
Objective To investigate the roles and mechanism of apoptosis and Bax,p53 ,C-myc protein expression of the peripheral blood mononuclear cells(PBMCs) in the genesis of systemic lupus erythematosus (SLE). Methods The apoptosis rate and Bax, p53, C-myc protein expression rate of PBMCs were detected by flow cytometry (FCM) in 20 SLE patients with active disease (SLE group)and 20 healthy controls (control group) ;The C3 serum level was detected quantitatively by turbidimentry, the association between the apoptosis rate of PBMCs and C3 serum level was analysed. Results The apoptosis rate of PBMCs and protein expression rate of Bax, p53, C-myc in SLE group were significantly higher than those in the control group( all P ＜ 0.01 ) ;The C3 serum level in SLE group was significantly lower than that in the control group ( all P ＜0.01 ) ,there was highly negative correlation between the apoptosis rate of PBMCs and the serum level of C3 in SLE group. Conclusion The expression of Bax,p53 ,C-myc protein play important role in the pathogenesis of SLE ,the possible mechanism maybe inducing apoptosis imbanlance and thereby lowing serum complement level.关键词
系统性红斑狼疮/外周血单个核细胞/细胞凋亡/凋亡基因Key words
systemic lupus erythematosus/ peripheral blood mononuclear cells/ apoptosis/ apoptin gene分类
医药卫生引用本文复制引用
李华,王吉波,姚媛,辛苗苗,梁宏达..SLE患者PBMCs细胞凋亡及其相关基因Bax、p53、C-myc蛋白表达的临床意义[J].山东医药,2011,51(3):24-25,2.基金项目
山东省医药卫生科研项目(HW027). （HW027）
