山东医药2011，Vol.51Issue(3)：15-17,3.
肺癌和癌前病变组织中FHIT、MSH2、p21蛋白表达及意义
Expression and significance of FHIT,MSH2 and p21 protein Expression in lung cancer and precancerous tissues
摘要
Abstract
Objective To investigate the roles of fragile histidine triad gene (FHIT),mutS homolog 2(MSH2) and p21 protein in the genesis and progross expression of lung cancer. Methods The expression of FHIT,MSH2 and p21 protein were detected by SP immunohistochemistry method , in tissues of 89 primary lung cancer( primary cancer group), 12 lymph node metastasis of lung cancer( metastatic carcinoma group ), 12 precancerous lesion (precancerous lesion group) and 10 normal control( control group), the relationship between the indexes and clinicopathological parameters were analyzed. Results Compared with control group, the expression of FHIT,MSH2 and p21 protein decreased in the other three groups(P ＜ 0.05) ;The expression of FH1T and MSH2 protein was related to tumor histologicol types and degree of cell differentiation ,the expression of p21 protein was related to the differentiation degrees,clinical stages and lymph node metastasis ( P ＜ 0.05) ;There was significantly positive correlation between FHIT and MSH2 protein ( P ＜0.01 ), but not obviously correlated with p21 protein. Conclusion The expression of FHIT ,MSH2 and p21 protein was related to the genesis and progress of lung cancer,joint detection of the three indexes may be useful to predict the development of lung cancer.关键词
肺肿瘤,肺癌/癌前病变/脆性组氨酸三联体/mutS同种组织蛋白2/p21蛋白Key words
lung neoplasms,lung cancer/ preeancerous lesion/ fragile histidine triad gene/ mutS homolog 2 protein/ p21 protein分类
医药卫生引用本文复制引用
袁玲,王新允,聂卫..肺癌和癌前病变组织中FHIT、MSH2、p21蛋白表达及意义[J].山东医药,2011,51(3):15-17,3.基金项目
天津市科委重点攻关课题资助项目(033804211). （033804211）
