山东医药2011，Vol.51Issue(3)：18-20,3.
RL联合PTX对重度失血性休克大鼠肺缺血再灌注损伤的影响
Effect of sodium lactate ringer's injection combined with pentoxifylline on lung ischemia-reperfusion injury in rats with serious hemorrhagic shock
摘要
Abstract
Objective Objective To explore the protective effect of sodium lactate ringer's injection(RL) combined with pentoxifylline(PTX) on lung ischemia-reperfusion injury in in rats with serious hemorrhagic shock. Methods A total of 48 healthy male SD rats were randomly divided into control group, model group, RL group and RL + PTX group, 12 in each group. The serious hemorrhagic shock models were reproduced in the latter three groups by the modified Wigger's method, then RL group was resuscitated with 3 × blood loss of RL. The same approach was applied to RL + PTX group,and PTX was dissolved in RL solution. The control group was only anesthetized. Respiratory index (RI) was detected respectively in pre-shock, pre-resuscitation, 1,2, 4 h after resuscitation; At 4 h after resuscitation, the rats were sacrificed damage scores. The pulmonary concentrations of matrix metalloproteinase-2 (MMP-2), IL-8 were determined in four groups. Results Compared with the control group, the lung damage score, the lung W/D, the lung permeability index were significantly increased in the other three groups, especially in the IL group and RL + PTX group ( all P ＜ 0.05 );Compared with the RL group, RI, the lung permeability index, the lung W/D, the lung injury score were significantly reduced, the lung histopathological change were significantly reduced, the pulmonary concentrations of MMP-2, IL-8 were lower in RL + PTX group( all P ＜ 0.05 ). Conclusion Resuscitation with RL + PTX c an significantly reduce lung ischemia-reperfusion injury in rats with serious hemorrhagic shock, the mechanism may be inhibiting the IL-8, MMP-2 generation of pulmonary to reduce inflammation response.关键词
休克,失血性/缺血再灌注损伤/己酮可可碱Key words
hemorrhagic shock/ ischemia-reperfusion injury/ pentoxifylline分类
医药卫生引用本文复制引用
杨木强,耿智隆,陆化梅,赵峰..RL联合PTX对重度失血性休克大鼠肺缺血再灌注损伤的影响[J].山东医药,2011,51(3):18-20,3.基金项目
全军"十一五"面上基金课题项目(06MA083). （06MA083）
