新医学2011，Vol.42Issue(1)：11-15,5.DOI:10.3969/g.issn.0253-9802.2011.01.005
对称动态动脉硬化指数对原发性高血压患者早期肾功能损害的预测
Symmetric ambulatory arterial stiffness index predicts early renal impairment in patients with essential hypertension
郭皓 1杨达宽 2田青 1王玮 1胡大春 3李勇国 1张鸿青 1杨悦林3
作者信息
- 1. 昆明市第一人民医院暨昆明医学院附属甘美医院心内科,650011
- 2. 昆明医学院第二附属医院胸心外科,650101
- 3. 昆明市第一人民医院暨昆明医学院附属甘美医院检验科,650011
- 折叠
摘要
Abstract
Objective: To investigate the relationship among symmetric ambulatory arterial stiffness index (S-AASI) , urine n-acetyl-β-D-glucosaminidase (NAG) and creatinine clearance rate (Ccr) in patients with essential hypertension.Methods: Three hundred patients with essential hypertension were enrolled.Ambulatory blood pressure monitoring (ABPM) was performed for S-AASI.Microproteinuria was quantified by urine NAG to creatinine ratio (NAG/Cr).Ccr was calculated with serum creatinine using Cockcroft-Gault formulation.The subjects were divided into four groups according to the S-AASI quartiles for comparison.Multivariate regression analysis was performed to confirm the association between renal impairment (using either NAG/Cr or Ccr) and S-AASI.Results: ① S-AASI increased with the age of the patients.No significant difference of the course of the essential hypertension was revealed between group A and B (P ＞ 0.05 ).However, significantly prolonged course was observed as S-AASI increased in group B, C and D (P ＜ 0.05).② Although no significant difference in serum creatinine was recorded among 4 groups, significantly successively increase and reduction were revealed in NAG/Cr and Ccr, respectively , as S-AASI increase in the 4 groups (P ＜ 0.05).③ Significantly independent correlations were revealed between S-AASI and NAG/Cr (β = 0.470, P ＜0.001) and Ccr (β = -0.322, P ＜0.05) according to multivariate regression analysis.With NAG/Cr increased by 1 IU/g, S-AASI was raised by 0.005.And with Ccr reduced by 1 ml/ (min · 1.73 m2), S-AASI was raised by 0.003.Conclusion: S-AASI is suggested as a predictive index in renal impairment of essential hypertension.关键词
原发性高血压/动态血压监测/动脉硬化/肾功能损害引用本文复制引用
郭皓,杨达宽,田青,王玮,胡大春,李勇国,张鸿青,杨悦林..对称动态动脉硬化指数对原发性高血压患者早期肾功能损害的预测[J].新医学,2011,42(1):11-15,5.
