山东医药2011，Vol.51Issue(11)：4-6,3.
动员后PBMC移植用于糖尿病与非糖尿病下肢动脉缺血性疾病治疗的效果比较
Effectiveness comparison of the mobilized PBMC transplantation on diabetic and non-diabetic patients with lower limbs ischemia
摘要
Abstract
Objective To investigate the effectiveness and mechanism of mobilized peripheral blood mononuclear cells (PBMCs)transplantation on the diabetics patients with lower limbs ischemia. Methods Twenty-three diabetics patients with lower limbs ischemia( diabetes group ) and 36 non-diabetics patients with lower limbs ischemia ( non-diabetes group)were included, and then were treated with mobilized PBMCs transplantation. All patients were counted the numbers of PBMCs and CD34+ cells before and after mobilization, also were evaluated with symptoms scores (rest pain, cold feeling, nopain walking distance and ucler) before and 7 days,4 months after therapy. Results The scores of rest pain, cold feeling,no-pain walking distance and ulcer in the two groups of 4 months after therapy were less than those before therapy, all P ＜0.05; no difference of symptoms scores were found between the two groups. The number of PBMCs before mobilization of the diabetes group and CD34+ cells were both lower than those of the non-diabetes group, both indexes decreased after the mobilization and no difference were found between the two groups. Conclusion The effectiveness of PBMCs transplantation on diabetics patients is definite,the mechanism I may related to that the mobilized PBMCs including more earlier endothelial progenitor cells(EPCs) and can offer the microenvironment for the proliferation of EPCs.关键词
单个核细胞/糖尿病/非糖尿病/移植/缺血分类
医药卫生引用本文复制引用
吴立华,张彦,黄平平,李尚珠,赵英新,龙凤雷,付仁敏,郑亚丽..动员后PBMC移植用于糖尿病与非糖尿病下肢动脉缺血性疾病治疗的效果比较[J].山东医药,2011,51(11):4-6,3.基金项目
国家人事部留学归国人员科技活动择优资助项目(国人厅发[2006]164号) （国人厅发[2006]164号）
天津市科技计划项目重大疾病防治专项(08ZCKFSF03200). （08ZCKFSF03200）
