中国康复理论与实践2011，Vol.17Issue(1)：39-41,3.
骨形态发生蛋白-4基因单核苷酸多态性与颈椎后纵韧带骨化症
Bone Morphogenetic Protein-4 Gene Polymorphism Associated with Ossification of Posterior Longitudinal Ligament in Chinese Patients
摘要
Abstract
Objective To explore the relationship of single nucleotide polymorphism (SNPs) of the bone morphogenetic protein-4 (BMP-4) gene with the morbidity and severity of the ossification of posterior longitudinal ligament (OPLL) of the spine in Chinese patients.Methods The venous blood samples of 200 OPLL patients and 200 non-OPLL controls were measured with the DNA sequences in four locus of BMP-4 gene with polymerase chain reaction(PCR).Results There was a significant association between the rs17563,rs2855532 polymorphism and the occurrence of OPLL (P＜0.05).The "T" allele in these 2 SNPs promotes the extent of OPLL (P＜0.05).However, no significant association in morbidity and severity was found between the other 2 SNPs (rs1957860,rs2071047).Conclusion SNPs in rs17563,rs2855532 associates with the morbidity and severity of the ossification of posterior longitudinal ligament of the spine in Chinese patients.关键词
后纵韧带骨化症/骨形态发生蛋白-4/基因/单核苷酸多态性分类
医药卫生引用本文复制引用
赵伟光,谢延平,闫亮,胡志恒,王浩,林欣..骨形态发生蛋白-4基因单核苷酸多态性与颈椎后纵韧带骨化症[J].中国康复理论与实践,2011,17(1):39-41,3.基金项目
国家自然科学基金(30872599) （30872599）
北京市自然科学基金(7092028). （7092028）
