首页|期刊导航|中国神经再生研究（英文版）|Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage
中国神经再生研究（英文版）2011，Vol.6Issue(1)：47-54,8.DOI:10.3969/j.issn.1673-5374.2011.01.008
Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage
Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage
摘要
Abstract
Numerous studies have demonstrated that endothelin-1 combines with endothelin receptor A,resulting in intense vasoconstriction.Although calcitonin gene-related peptide (CGRP) suppresses endothelin-1,CGRP and endothelin receptor A exhibit direct biological effects on brain tissue.The present study analyzed CGRP and endothelin receptor A expression following subarachnoid hemorrhage in rabbits using immunohistochemistry.CGRP expression was significant at 5 days after model establishment,and endothelin receptor A expression was significant at 3 days after model induction.The perimeter of the basilar artery was measured to determine the amount of cerebral vasospasm.Analytical results revealed a significantly shortened basilar artery perimeter following subarachnoid hemorrhage.Changes in the basilar artery perimeter were negatively associated with endothelin receptor A expression,but positively correlated with CGRP expression in vessels.These results suggest that following subarachnoid hemorrhage:CGRP and endothelin receptor A expressions dynamically changed in brain vessels and tissues,although these changes were not synchronous.Changes in endothelin receptor A expression exhibited a significant effect on the occurrence and development of delayed cerebral vasospasm and delayed neuronal death,while CGRP relaxed vessels and protected nerves.关键词
calcitonin gene-related peptide/endothelin receptor A/subarachnoid hemorrhage/cerebral vasospasm/brain injury/neural regenerationKey words
calcitonin gene-related peptide/endothelin receptor A/subarachnoid hemorrhage/cerebral vasospasm/brain injury/neural regeneration引用本文复制引用
Jinning Song,Ming Zhang,Qi Liang,Long Sui,Lei Xi,Wenbo Wang..Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage[J].中国神经再生研究（英文版）,2011,6(1):47-54,8.基金项目
the National 863 Project of China,No.2006AA02Z4Z4 （）
the National Natural Science Foundation of China,No.30870844 （）
the New Century Excellent Talent Support Project of Ministry of Education,No.NCET-05-0831 （）
the "13115" Special Fund for Major Science and Technology Projects of Shaanxi Province,No.2008ZDKG-66 （）
