中国神经再生研究（英文版）2011，Vol.6Issue(1)：55-59,5.DOI:10.3969/j.issn.1673-5374.2011.01.009
Apoptotic gene expression in the neural tube during early human embryonic development
Apoptotic gene expression in the neural tube during early human embryonic development
Guifang Chen 1Tiandong Li 1Peipei Ding 2Ping Yang 2Xiao Zhang2
作者信息
- 1. Department of Life Science and Technology,Mianyang Normal University,Mianyang 621000,Sichuan Province,China
- 2. Department of Experiment and Technique,Chengdu Medical College,Chengdu 610083,Sichuan Province,China
- 折叠
摘要
Abstract
Neural tube development comprises neural induction,neural epithelial cell proliferation,and apoptosis,as well as migration of nerve cells.Too much or too little apoptosis leads to abnormal nervous system development.The present study analyzed expression and distribution of apoptotic-related factors,including Fas,FasL,and caspase-3,during human embryonic neural tube development.Experimental results showed that increased caspase-3 expression promoted neural apoptosis via a mitochondriai-mediated intrinsic pathway at 4 weeks during early human embryonic neural tube development.Subsequently,Fas and FasL expression increased during embryonic development.The results suggest that neural cells influence neural apoptosis through synergistic effects of extrinsic pathways.Therefore,neural apoptosis during the early period of neural tube development in the human embryo might be regulated by the death receptor induced apoptotic extrinsic pathways.关键词
apoptosis/caspase-3/Fas/human embryo/neural tube development/quantitative reverse transcription polymerase chain reactionKey words
apoptosis/caspase-3/Fas/human embryo/neural tube development/quantitative reverse transcription polymerase chain reaction引用本文复制引用
Guifang Chen,Tiandong Li,Peipei Ding,Ping Yang,Xiao Zhang..Apoptotic gene expression in the neural tube during early human embryonic development[J].中国神经再生研究（英文版）,2011,6(1):55-59,5.
