中国神经再生研究（英文版）2011，Vol.6Issue(1)：41-46,6.DOI:10.3969/j.issn.1673-5374.2011.01.007
Foxg1 mRNA overexpression in neonatal rats following hypoxic brain injury
Foxg1 mRNA overexpression in neonatal rats following hypoxic brain injury
摘要
Abstract
Forkhead box G1 (Foxg1) is expressed during the embryonic stage and in postnatal brain regions sensitive to hypoxia/ischemia injury,such as the hippocampus and cerebral cortex.To date,very little is known about Foxg 1 expression changes in the brain following hypoxia injury (HI).The present study measured Foxg 1 mRNA expression using reverse-transcription polymerase chain reaction on days 3,7,14,28,and 56 following HI to determine self-restorative features in the injured brain.In addition,mRNA expression of other related layer markers,such as Reelin,RORB,Foxp1,Foxp2,ER81,and Otx-1,was detected following HI.Results revealed significantly decreased Foxg1 mRNA expression at 3 days after HI,which significantly increased by 56 days.Reelin and Foxp2 mRNA expression were upregulated until 56 days after HI,but Foxp1 and ER81 mRNA expression decreased from day 14 to 56 following HI.In addition,Otx-1 and RORB mRNA expression decreased from day 3 to 28 after HI.These findings revealed Fxog1 mRNA overexpression and varying degrees of restoration in the neonatal rat brain following HI.关键词
Foxg1 mRNA/hypoxia injury/neonatal rats/cerebral cortexKey words
Foxg1 mRNA/hypoxia injury/neonatal rats/cerebral cortex引用本文复制引用
Luquan Li,Yi Zheng,Guoliang Mo,Fang Li,Jialin Yu..Foxg1 mRNA overexpression in neonatal rats following hypoxic brain injury[J].中国神经再生研究（英文版）,2011,6(1):41-46,6.基金项目
the Key Medical Disciplinary Areas Foundation of Chongqing,No.2010-53 （）
