临床小儿外科杂志2011，Vol.10Issue(1)：36-38,3.DOI:10.3969/j.issn.1671-6353.2011.01.011
乌司他丁对婴幼儿体外循环细胞免疫功能的保护作用
Protective effects of ulinastatin on cellular immune function in infants underwent cardiac operations with cardiopulmonary bypass
摘要
Abstract
Objective To observe the change of T lymphocyte immunity functions after cardiopulmonary bypass (CPB) in infants, and to evaluate the protective effects of ulinastatin on cellular immune function.Methods From Jan. 2010 to Jun. 2010, there were 50 infants with ventricular septal defects, whom divided randomly into the Ulinastatin group or Control, enrolled into this prospective trial. And infants from the ulinastatin group were treated with 1 000 U/kg which was added into the CPB priming fluid during the correct operations. Blood samples were taken at different time points for the analysis of T lymphocyte and its subtype by flow cytometry. Results 24 hours after the correct operations, and compared with the control group, infants from the ulinastatin group had higher levels of CD4 + , CD3 + and CD4 +/CD8 + , as well as a lower level of CD8 + .And 7 days late, the levels of CD4 + , CD3 + and CD4 +/CD8 + in the ulinastatin group were still higher than those in the control group. Conclusions Administration of ulinastatin in the CPB priming fluid can attenuate the inhibition of T lymphocyte immunity functions caused by CPB in infants.关键词
体外循环/淋巴细胞/免疫学/婴儿引用本文复制引用
陈仁伟,祝兴元,周文武,刘平波,高纪平..乌司他丁对婴幼儿体外循环细胞免疫功能的保护作用[J].临床小儿外科杂志,2011,10(1):36-38,3.基金项目
本课题受湖南省自然科学基金资助(项目号06TJ41078) （项目号06TJ41078）
