兰州大学学报（医学版）2011，Vol.37Issue(1)：25-30,6.
胃癌Smad4、CyclinD1和P21waf1表达意义及其与生存的关系
Correlations of smad4, CyclinD1 and p21waf1 expression to prognosis of gastric carcinoma
摘要
Abstract
Objective To evaluate the expression patterns of Smad4, CyclinD1, p21waf1 protein in gastric carcinoma and determine the relationship between Smad4, CyclinD1, p21waf1, tumor clinicopathological features and patient survival as well. Methods The expression of Smad4,CyclinD1 and p21waf1 protein was detected by S-P immunohistochemistry and tissue microarray in 200 specimens of primary human gastric carcinoma and 56 adjacent gastric tissues. Results The abnormal expression rates of Smad4, CyclinD1 and p21waf1 protein in the tissues of gastric carcinoma were 67.0％, 56.5％ and 59.5％ respectively. Smad4 expression level was lower in poorly-differentiated and diffuse gastric carcinoma than in highly-differentiated and intestinal gastric carcinoma (P ＜0.01). The higher expression of CyclinD1 was associated with lymph node metastasis, poorly-differentiated and diffuse gastric carcinoma (P ＜0.05). The exprcssion level of p21waf1 in poorly-differentiated and diffuse gastric carcinoma was lower than in highlydifferentiated and intestinal gastric carcinoma (P ＜0.05). Significant correlation were observed between Smad4 and p21waf1 expression(r=0.179, P ＜0.05). Smad4 positive expression was associated with favorable survival (P ＜0.05). Conclusion Abnormal expressions of transforming growth factor-Smad4 signaling pathway occurs in gastric carcinoma. Smad4 may influence gastric carcinoma by regulating p21waf1 and transition of cell cycle regulation G1/S and finally result in tumorigenesis. Positive expression of Smad4 is a favorable prognostic factor, but not an independent one in patients with gastric carcinoma.关键词
胃癌/Smad4/CyclinD1/p21waf1/临床病理学/生存期Key words
gastric carcinoma/ smad4/ cyclinD1/ p21waf1/ clinicopathology/ survival分类
医药卫生引用本文复制引用
李强,郭庆红,路红,姬瑞,张宏玲,赵越,张志镒,周永宁..胃癌Smad4、CyclinD1和P21waf1表达意义及其与生存的关系[J].兰州大学学报（医学版）,2011,37(1):25-30,6.基金项目
甘肃省自然科学基金(0803RJZA056) （0803RJZA056）
