临床口腔医学杂志2011，Vol.27Issue(1)：20-22,3.DOI:10.3969/j.issn.1003-1634.2011.01.007
大鼠舌癌癌变过程中琥珀酸脱氢酶的表达变化
Changes in succinate dehydrogenuse gene expression during 4-nitroquinoline 1-oxide induced rat tongue carcinogenesis.
摘要
Abstract
Objective: To observe the different expression of Succinate dehydrogenase (SDH) during oral carcinogenesis, analyze the relationship between the abnormal expression of SDH, and the occurrence and development of oral carcinogenesis. Method: Real-time quantitative PCR was employed to detect the gene expression of SDH in 38 rat tongue carcinogenesis specimens induced by 4-nitroquinoline 1-oxide. Result: with the progress of tongue carcinogenesis, the expression of SDH was down-regulated, in normal, Mild epithelial dysplasia、 Moderate epithelial dysplasia, severe epithelia] dysplasia and squamous cell carcinoma (SCC). There was significant differences between normal and Moderate epithelial dysplasia、severe epithelial dysplasia and SCC,P ＜0.01 or P ＜0.05).Them was a significant correlation between the decreased expression levels of SDH gene and histopathological grade (P ＜0.01). Conclusion: The down expression of SDH gene may be correlated to the occurrence and the development of oral carcinoma, suppressed Tricarboxylic acid cycle might in the development or progression of oral cancer.关键词
口腔癌变/琥珀酸脱氢酶/实时荧光定量PCR/4-硝基喹啉-1-氧化物Key words
oral carcinogenesis/ Succinate dehydrogenase/ Real-time quantitative PCR/ 4-nitrocluinoline 1-oxide分类
医药卫生引用本文复制引用
葛姝云,娄佳宁,周曾同..大鼠舌癌癌变过程中琥珀酸脱氢酶的表达变化[J].临床口腔医学杂志,2011,27(1):20-22,3.基金项目
国家自然科学基金青年项目(30700944)上海市重点学科建设项目基金资助(S30206) （30700944）
