医药导报2011，Vol.30Issue(3)：294-297,4.DOI:10.3870/yydb.2011.03.008
八角茴香挥发油经皮渗透性及对布洛芬透皮吸收的影响
Transdermally Permeability of Star Anise Oil and Its Effect on Percutaneous Absorption of Ibuprofen
刘梅 1王庆伟 1刘雪英 2孙阳阳 3回广飞 3崔前斌 3李辉3
作者信息
- 1. 第四军医大学唐都医院药剂科,西安,710038
- 2. 第四军医大学药学系药物化学教研室,西安,710032
- 3. 第四军医大学药学系学员队,西安,710032
- 折叠
摘要
Abstract
Objective To study the transdermal characteristics of star anise oil and its percutaneous penetration enhancement for ibuprofen. Methods To establish a method for determination of ibuprofen and anethole , the major constituent of star anise oil by HPLC. Fetal skin was used as permeation barrier in vitro. The transdermal properties of the star anise oil and its effect on percutaneous penetration of ibuprofen were investigated by using Franz diffusion cells . Results The permeability coefficients of star anise oil at 0.5％ ,1.0％ , 2.0％ were (1.675 ± 0.331) , (4.048 ± 0.579) , (5.352 ± 0.166) [μg·(cm) · h , respectively. The permeability coefficients of ibuprofen with star anise oil at 0.0％ , 0.5％ , 1.0％ , 2.0％ were (9.416±1.260) ,(7.803±l.128) ,(9.495±0.749) ,(7.334 ± 0.885) |xg- (cm2)-1- h-1, respectively. Conclusions Star anise oil and ibuprofen could well penetrate through fetal skin in a dose dependent manner . Star anise oil does not show transdermal enhancing effects , while inhibits the percutaneous absorption of ibuprofen in vitro.关键词
八角茴香油/茴香脑/布洛芬/透皮吸收分类
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刘梅,王庆伟,刘雪英,孙阳阳,回广飞,崔前斌,李辉..八角茴香挥发油经皮渗透性及对布洛芬透皮吸收的影响[J].医药导报,2011,30(3):294-297,4.
