针灸临床杂志2011，Vol.27Issue(1)：52-54,3.
艾灸预处理对全脑缺血再灌注大鼠模型一氧化氮合酶活性的影响
Effects of Moxibustion Preconditioning on NOS in Rats with Global Cerebral Ischemia-reperfusion Injury
摘要
Abstract
Objective: To observe the effects of moxibustion preconditioning on NOS in rats with Global cerebral ischemia- repeffusion injury. Methods: 150 Wistar rats were divided into control group, sham operated group, ischemia- repeffusion (IR group), ischemie preconditioning group( IP group), moxibustion preconditioning group( MP group) by means of random number table. The activity of iNOS and nNOS in injuried brain tissue was determined by chemical colorimetry at 24h ,48h and 72h after cerebral ischemia - repeffusion. Results:At 24 h ,48 h and 72 h post ischemia -reperfusion, the activity of iNOS and nNOS in IR group, IP group,MP group were significantly increased as compared with that in control group and sham operated group (P ＜0. 01 ). At 48 h,72 h post ischemia - reperfusion, the activity of iNOS and nNOS in IP group, MP group were significantly decreased as compared with that in IR group( P ＜0.01 ) ,but there was no significant difference between IP group and MP group( P ＞ 0.05 ). Conclusion :These results show that the ability of moxibustion preconditioning for inhibiting the activity of NOS is the same as that of ischemia - reperfusion , suggesting that moxibustion preconditioning is an effective means for inducing cerebral ischemic tolerance.关键词
艾灸预处理/脑缺血再灌注/大鼠/一氧化氮合酶分类
医药卫生引用本文复制引用
孙忠人,王振宇,华金双..艾灸预处理对全脑缺血再灌注大鼠模型一氧化氮合酶活性的影响[J].针灸临床杂志,2011,27(1):52-54,3.基金项目
国家自然科学基金面上项目,编号:30873298 （）
黑龙江省教育厅海外学人科研资助项目,编号:1151hz010. （）
