中国药业2011，Vol.20Issue(3)：8-10,3.
花椒多酚类化合物对慢性应激抑郁大鼠的治疗作用机制研究
Analysis of Antidepressant Effects and Possible Mechanisms of ZPPC in Chronically Stressed Rats
周皎 1木海鸥 2王玮2
作者信息
- 1. 浙江省温州市第三人民医院,浙江,温州,325000
- 2. 温州医学院附属第二医院,浙江,温州,325027
- 折叠
摘要
Abstract
Objective To investigate the antidepressant effects of ZPPC and its possible mechanism.Methods Forty SD rats were randomly divided into normal group, model group, three groups treated with ZPPC (50, 100,200g/kg) and imipramine group(10mg/kg).The chronically stressed model was established, and the activities in the open- field box and forced swimming test were observed respectively.Determining the levels of corticosterone and IL- 1β in stressed rats using the ELISA method, and then measuring the thickness of adrenal gland cortex of stressed rats.Results Compared with the chronically stressed rats, the low, middle and high doses of ZPPC significantly reversed the depressive- like behaviors of stressed rats, which can increase the reactivity in open- field box, and reduce the immobility time in the forced swimming test.Furthermore, ZPPC treatments inversed the stressed-induced increase of corticosterone and IL-1β levels(all P＜0.05, P＜0.01, P＜0.001).ZPPC treatments also decreased the thickness of adrenal gland cortex(all P＜0.01).Conclusion ZPPC has significant antidepressant effects,which is probably related to the improvement of the immunity functions and the protection of adrenal.关键词
花椒多酚类化合物/慢性应激/皮质酮/肾上腺/白细胞介素1β分类
医药卫生引用本文复制引用
周皎,木海鸥,王玮..花椒多酚类化合物对慢性应激抑郁大鼠的治疗作用机制研究[J].中国药业,2011,20(3):8-10,3.
