四川大学学报（医学版）2011，Vol.42Issue(1)：37-40,4.
栀子和善宁联合应用对重症急性胰腺炎大鼠线粒体损伤的影响
Effects of the Combination of Sandostatin and Gardenia Jasminoides Ellis on Pancreatic Mitochondria Injury in Severe Acute Pancreatitis Rats
摘要
Abstract
Objective To study the protective effects of the combination of sandostatin(SS) and gardenia jasminoides ellis (GJE) on pancreatic mitochondria injury in severe acute pancreatitis(SAP) rats.Methods SAP rat model was induced by retrograde injection of 15 g/L sodium deoxycholate into biliary tract.The rats were randomly divided into five groups: SAP group, Sham group, SS group, GJE group, as well as SS and GJE combination group.The changes of Superoxide dismutase (SOD), succinic dehydrogenase (SDH), Na+-K+-ATPase, Ca2+-Mg2+-ATPase, malondialdehyde(MDA), membrance fluidity of mitochondria in pancreatic tissue were measured.Results Compared to Sham group, the activities of SOD, SDH, Na+-K+-ATPase and Ca2+-Mg2+-ATPase in mitochondria were obviously decreased in SAP group, and MDA and microviscosity(η) were markedly increased(P＜0.01), which were associated with the increase of serum amylase level(P＜0.01).The above-mentioned indexes of GJE group, SS group and combination group were obviously ameliorated in comparison with SAP group (P＜0.01), the improvement in combination group was the best (P＜0.05 or P＜0.01).The correlation analysis indicated that MDA was negatively correlated with SOD, membrance fluidity, as well as the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase(r＝ -0.857, P＜0.01;r＝-0.960, P＜0.01;r＝-0.966, P＜0.01; r＝-0.926, P＜ 0.01).Conclusion The combination of sandostatin and gardenia jasminoides ellis can protect pancreatic mitochondria injury in severe acute pancreatitis.关键词
胰腺炎/脂质过氧化/线粒体/栀子/善宁/中西医结合Key words
Pancreatitis/ Lipid peroxide/ Mitochondria/ Gardenia jasminoides ellis/Sandostatin/ Combined Chinese and western medicine引用本文复制引用
王艳蕾,刘建宇,景友玲,张一兵,孙娜,王小君..栀子和善宁联合应用对重症急性胰腺炎大鼠线粒体损伤的影响[J].四川大学学报（医学版）,2011,42(1):37-40,4.基金项目
河北省教育厅基金(批准号Z2006311)和唐山市科技局基金(批准号06134601b-41)资助 （批准号Z2006311）
