解放军医学杂志2011，Vol.36Issue(1)：80-82,3.
儿童胆管消失综合征24例临床病理分析
The clinical and pathological analysis of 24 children with vanishing bile duct syndrome
刘树红 1赵景民 1周光德 1赵雨来 1李文淑 2郭晓东 1梁丽 1熊璐 1韦立新3
作者信息
- 1. 100039,北京,解放军302医院病理诊断与研究中心
- 2. 100039,北京,解放军302医院新药临床实验中心
- 3. 100853,北京,解放军总医院病理科
- 折叠
摘要
Abstract
Objective To investigate the clinical and pathological characteristics of vanishing bile duct syndrome (VBDS), and provide references for clinical diagnosis.Methods Twenty four children with VBDS diagnosed by liver biopsy were collected in 302 Hospital of PLA from 2007 to 2009.Liver tissues were stained with haematoxylin eosin staining.The clinical and pathological characteristics were analyzed.Results The mean age of all patients (mean SD) was 4.08±3.11 years and the sex ratio (male to female)was 2.4 : 1.The most common symptoms were jaundice and pruritus in 24 children with VBDS The mean levels of ALT, AST, ALP,GGT and TBil were 203.45 239.42U/L, 238.54 224.11U/L, 524.04 300.96U/L, 242.17 220.86U/L and 242.17 220.86 μmol/L,respectively.Nineteen of 24 cases were positive for anti-CMV IgM, anti-CMV/IgG or CMV PP65.Five cases were undergone the operation of biliary atresia.The main pathological characteristic of VBDS was atresia or disappearance of interlobular bile ducts to various degrees.Moreover, histological changes varied with respect to different causes.Obvious inflammatory infiltration in the portal tracts and hepatocytes damage were more common in VBDS caused by cytomegalovirus (CMV) infection.Conclusions The incidence of VBDS is higher in boys than in girls.CMV infection plays an important role in the progress of VBES Different pathological characteristics may exist in VBDS caused by different etiological factors.关键词
胆管消失综合征/儿童/病理学/临床Key words
vanishing bile duct syndrome/ child/ pathology/ clinical分类
医药卫生引用本文复制引用
刘树红,赵景民,周光德,赵雨来,李文淑,郭晓东,梁丽,熊璐,韦立新..儿童胆管消失综合征24例临床病理分析[J].解放军医学杂志,2011,36(1):80-82,3.
