医药导报2011，Vol.30Issue(2)：210-213,4.DOI:10.3870/yydb.2011.02.024
舒芬太尼和瑞芬太尼复合丙泊酚静脉麻醉用于神经外科手术的对比
Propofol-sufentanil versus Propofol-remifentanil as Total Intravenous Anesthesia for Neurosurgery
毕江江 1罗爱林 1樊龙昌 1江辉1
作者信息
- 1. 华中科技大学同济医学院附属同济医院麻醉科,武汉,430030
- 折叠
摘要
Abstract
Objective To compare the efficacy and postoperative analgesia of either sufentanil or remifentanil combined with propofol as total intravenous anesthesia in patients undergoing nonemergency neurosurgery. Methods 80 patients of ASA Class Ⅰ-Ⅱ who were scheduled for a neurosurgery were randomized into two groups: sufentanil(S) group and remifentanil(R) group. Anesthesia was induced with propofol and either sufentanil 0.25 (μg · kg-1 or remifentanil 1 (μg · kg-1. Infusion rate of propofol were 6-10 mg · kg-1 · h-1 in both groups. Maintenance infusion rates for sufentanil and remifentanil were 0.0025 μg · kg-1 · min-1 and 0.1 - 0.2 μg · kg-1 · min-1, respectively. Patients' hemodynamic condition was monitored throughout the anesthesia procedure. And the awakening time, extubation time, postoperative complications,visual analogue scale (VAS)and tramadol consumption were recorded. Results The awakening and extubation time in R group were significantly shorter than those in S group (6.4±2.5) , (11.6±5.3) min vs( 12.6±6.4) , (16.2±7.4) min( P＜0.05). Side effects in both groups showed no significant difference within 6 h after extubation. Tramadol consumption for postoperative pain relief in R group was greater than in S group [(557.6±54.3) mg] vs [ (312.4±47.7) mg] (P＜0.05). VAS of 60,90,120 min postoperation in S group were lower than those in R group(P＜0.05). Conclusion Total intravenous anesthesia by using either sufentanil or remifentanil in combination with propofol can be effectively applied in neurosurgery, with a faster awakening time by remifentanil and a satisfactory postoperative analgesia effect by sufentanil.关键词
舒芬太尼/瑞芬太尼/丙泊酚/手术,神经外科/麻醉分类
医药卫生引用本文复制引用
毕江江,罗爱林,樊龙昌,江辉..舒芬太尼和瑞芬太尼复合丙泊酚静脉麻醉用于神经外科手术的对比[J].医药导报,2011,30(2):210-213,4.
