中国药房2011，Vol.22Issue(6)：523-525,3.
纳洛酮治疗慢性阻塞性肺疾病Ⅱ型呼吸衰竭患者脑电图异常的疗效研究
Study on Efficacy of Naloxone with Electroencephalogram Disorder in Patients with COPD and Type II Respiratory Failure
摘要
Abstract
OBJECTIVE: To study the efficacy of naloxone with electroencephalogram (EEG) disorder in patients with chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure.METHODS: 141 patients with COPD and type Ⅱ respiratory failure were randomly divided into two groups: 71 cases in treatment group and 70 cases in control group.In treatment group,naloxone 2 mg was administered by intravenous infusion once a day while in control group nikethamide 1.125 g and lobeline 9 mg were also administered by intravenous infusion once a day.The treatment course was 7 days.The blood gas analysis and EEG changes of two groups were compared before and after treatment.RESULTS: PaCO2 and PaO2 of treatment group had a more remarkable improvement than those of control group (P=0.01, P=0.02).The effective rates of EEG improvement were 85.9％ and 67.1％, respectively.There was a significant difference (P=0.008).CONCLUSIONS: The treatment group has a more remarkable improvement in EEG than control group and no adverse drug reactions after this course.关键词
纳洛酮/慢性阻塞性肺疾病/呼吸衰竭/脑电图分类
医药卫生引用本文复制引用
赵明栋,张玲,张宇翔,夏伟,孙玉梅,杜培静,潘以雄,张学群,陈腊年..纳洛酮治疗慢性阻塞性肺疾病Ⅱ型呼吸衰竭患者脑电图异常的疗效研究[J].中国药房,2011,22(6):523-525,3.基金项目
宜昌市2008年医疗卫生科技计划项目(A08302-18) （A08302-18）
