重庆医学2011，Vol.40Issue(4)：328-330,封2,4.DOI:10.3969/j.issn.1671-8348.2011.04.006
Caveolin-1蛋白及mRNA在食管鳞状细胞癌组织中的表达
Expression of Caveolin-1 protein and mRNA in esophageal squamous cell carcinoma tissue
楚广民 1庞霞 2高冬玲2
作者信息
- 1. 河南省肿瘤医院病理科,郑州,450008
- 2. 郑州大学第一附属医院病理科/河南省肿瘤病理重点实验室,450052
- 折叠
摘要
Abstract
Objective To investigate the expressions of Caveolin-1 protein and mRNA in esophageal squamous cell carcinoma (ESCC)tissues and its significance. Methods The expressions of Caveolin-1 protein and mRNA was detected by immunohistochemistry and in situ hybridization methods in 57 cases of ESCC tissues, 34 cases of adjacent atypical hyperplasia epithelial tissues and 57 cases of normal esophageal epithelial tissues. Results The positive expression rate of Caveolin-1 protein gradually decreased from 54.4％(31/57)in ESCC,38.2％(13/34)in adjacent atypical hyperplasia epithelium to 19.3％ (11/57)normal esophageal epithelium specimens, and there was a significant statistic difference among the groups(P＜0.05). Additionally, the expression rates of Caveolin-1 mRNA decreased by turns from ESCC,adjacent atypical hyperplasia epithelium to normal esophageal epithelium specimens, which were 64.9 ％ (37/57), 47.1％ (16/34) and 22.8 ％ (13/57) respectively, and there was a significant statistic difference among the groups(P＜0.05). The expressions of Caveolin-1 protein and mRNA were closely correlated with the different differentiation levels,infiltrative depth and lymph node metastasis in ESCC tissues(P＜0.05). Conclusion The expressions of Caveolin-1 protein and mRNA may play important roles in the infiltration,metastasis and carcinogenesis of ESCC,suggesting it may be usedas a tumor makerof ESCC. Combined detections of Caveolin-1 protein and mRNA have some clinical value in assessing the prognosis of ESCC.关键词
窖蛋白1/肿瘤,鳞状细胞/免疫组织化学/原位杂交Key words
Caveolin-1/ carcinoma/ squamous cell/ immunohistochemistry / in situ hybridization引用本文复制引用
楚广民,庞霞,高冬玲..Caveolin-1蛋白及mRNA在食管鳞状细胞癌组织中的表达[J].重庆医学,2011,40(4):328-330,封2,4.
