中国实用儿科杂志2011，Vol.26Issue(3)：218-220,3.
单纯性肥胖血浆同型半胱氨酸与血脂变化及其与心脑血管疾病相关性研究
Study of the change of plasma HCY and serum lipid and their correlation in obese children
张丽娟 1马路一 1孙国华 2吕磷琳2
作者信息
- 1. 大连医科大学附属第一医院儿科,辽宁大连,116011
- 2. 大连医科大学附属第一医院检验科,辽宁大连,116011
- 折叠
摘要
Abstract
Objective To study the changes of plasma homocysteine, serum lipid in simple obese children, and the relations between plasma homocysteine, serum lipid and cardiovascular and cerebrovascular diseases, and to provide a new path to prevent and cure the simple obesity in children and cardiovascular and cerebrovascular diseases in adulthood.Methods Thirty-four cases of simple obese children were collected in the First Affiliated Hospital of Dalian Medical University from December 2008 to December 2009,25 cases of healthy children were selected in our study in the same period.Liver morphology was detected by Color Doppler ultrasound.Venous blood was taken after 12 hours fasting.The levels of total plasm homocysteine (HCY), cholesterol (TC), triglyceride (TG), high-density lipoprotein ( HDL-Ch),low-density lipoprotein (LDL-Ch) and plasma lipoprotein (a)[LP (a)]were determined.Results Liver morphology changed in 18 cases of simple obese children, while only 1 in healthy children.TC, TG and LDL-Ch in simple obese children were significantly higher than those of control group, the difference being statistically significant (P ＜ 0.05).Serum HDL-Ch and LP(a) between the two groups had no obvious difference(P ＞ 0.05).The levels of plasma HCY in the simple obese children[( 10.91 ± 2.57) μmol/L]was significantly higher than control group [(5.13 ± 1.12) μmol/L](P ＜ 0.05 ).The level of plasma HCY and blood lipid had no obvious relevance.Conclusion Simple obese children are more susceptible to suffer from fatty liver than healthy children; it is closely related to the lipid metabolism.The level of HCY is significantly higher in simple obese children, which has no obvious relevance to blood lipid, and it is one of independent risk factors of cardiovascular and cerebrovascular diseases.关键词
单纯性肥胖/同型半胱氨酸/血脂/脂肪肝分类
医药卫生引用本文复制引用
张丽娟,马路一,孙国华,吕磷琳..单纯性肥胖血浆同型半胱氨酸与血脂变化及其与心脑血管疾病相关性研究[J].中国实用儿科杂志,2011,26(3):218-220,3.
