实用医学杂志2011，Vol.27Issue(6)：957-959,3.DOI:10.3969/j.issn.1006-5725.2011.06.013
米诺环素对实验性自身免疫性脑脊髓炎大鼠轴索损伤的影响
Effects of minocycline on axonal injury in rats with experimental autoimmune encephalomyelitis
摘要
Abstract
Objective To investigate the effects of minocycline on axonal injury in rats with experimental autoimmune encephalomyelitis (EAE). Methods EAE was indced in rats by immunization with guinea pig spinal cord homogenate (GPSCH), and then the rats were divided into treatment group, model group, and control group.Rats in treatment group were given minocycline,while rats in the other two groups were given normal saline by gavage.The expression of β-amyloid precursor protein (β-App) was estimated by immunohistochemical method.Results The positive cells in spinal cord were higher in model group than those in the other two groups (P ＜0.05), and those in brain and brain stem were significantly higher in model group than those in control group (P ＜0.05 ) .The average density in spinal cord, brain, and brain stem in model group were significantly higher than those in the other two groups (P ＜ 0.05). Conclusions Minocycline can regulate the expression of β-App and may have protective effects on axonal injury in EAE.关键词
脑脊髓炎/自身免疫性/实验性/多发性硬化/米诺环素/轴索损伤/β-App引用本文复制引用
周建波,曾丽,曾广凌,张贵强..米诺环素对实验性自身免疫性脑脊髓炎大鼠轴索损伤的影响[J].实用医学杂志,2011,27(6):957-959,3.基金项目
广西自然科学基金资助项目(编号:桂科自0542088) （编号:桂科自0542088）
