中国组织工程研究与临床康复2011，Vol.15Issue(7)：1237-1240,4.DOI:10.3969/j.issn.1673-8225.2011.07.021
磷脂多不饱和脂肪酸抑制兔耳增生性瘢痕
Phospholipid polyunsaturated fatty acid inhibits hypertrophic scar in rabbit ears
彭智 1唐红伟 1黄海华 1郭晓瑞 1韦有万 1吴志远 1张培华1
作者信息
- 1. 广东医学院附属医院整形外科,广东省湛江市,524001
- 折叠
摘要
Abstract
BACKGROUND: Phospholipid polyunsaturated fatty acid (Phospholipid-PUFA) can inhibit the cell inflammatory response and immune function. The formation of hypertrophic scars has contact with inflammation, cellular immunity and cytokines closely.However, there are few studies addressing Phospholipid-PUFA on hypertrophic scars.OBJECTIVE: To explore the inhibiting effect of phospholipid-PU FA on rabbit ear hypertrophic scar.METHODS: Nine New Zealand rabbits were chosen to establish animal models of hypertrophic scars. Six round full-thickness wounds in sizes of 1 cm×1 cm were made in the ventral surface of each ear. Totally 108 wound were prepared, and formed 92 hypertrophic scars, with scar formation rate of 85％. Every 3 wounds in each front ear were treated by phospholipid-PUFA cream,those at the behind of right ear was treated by mult-acid mucopolysaccharide cream, once per day, the rest served as control.The wound healing was observed at 28, 42, 63 and 90 days after operation. The thickness of scars, collagen fiber and density of fibroblasts were observed under a microscope. The expression of collagen fiber was detected by immunohistochemistry.RESULTS AND CONCLUSION: Compared with the control group, the volume of hypertrophic scar was minificated, thinner, the density of fibroblasts was diminished, and the expression of collagen fiber was decreased in the experimental groups, especially obviously in the phospholipid-PUFA group, suggesting phospholipid-PUFA can inhibit hypertrophic scar formation and reduce scar hyperplasia.关键词
磷脂多不饱和脂肪酸/增生性瘢痕/动物模型/兔/皮肤组织工程分类
医药卫生引用本文复制引用
彭智,唐红伟,黄海华,郭晓瑞,韦有万,吴志远,张培华..磷脂多不饱和脂肪酸抑制兔耳增生性瘢痕[J].中国组织工程研究与临床康复,2011,15(7):1237-1240,4.
