临床肝胆病杂志2011，Vol.27Issue(2)：136-139,4.
脾动脉阻断技术在射频消融治疗门脉高压性脾功能亢进症中的应用
The application of occlusive techniques of the splenic artery combined with radiofrequency ablation for hypersplenism due to portal hypertension
摘要
Abstract
Objective To investigate the efficacy and clinical prospects of occlusion of the splenic artery combined with radiofrequency ablation (RFA) for severe hypersplenism in patients with liver cirrhosis and portal hypertension.Methods The patients undergoing splenic RFA with or without simultaneous splenic artery occlusion were followed-up over a 6-month period to assess the clinical efficacy; the roles of splenic artery occlusion on splenic artery steal syndrome also were evaluated.Results Two groups of with or without splenic artery occlusion recruited fifteen patients each undergoing splenic RFA, no procedurerelated complications occurred.The ablated splenic volume markedly increased in patients with splenic artery occlusion (56±35)％,compared with patients without splenic artery occlusion (38±21)％ (P＜0.01); the patients undergoing RFA with splenic artery occlusion had more significant increase of platelet counts, and better improvement of Child-Turcotte-Pugh classification and score,compared with patients without splenic artery occlusion.The diagnosis of splenic artery steal syndrome was confirmed on radiologic imagings in all the 15 patients with massive splenomegaly, after occlusion of the splenic artery by splenic artery coil emoblization in 13 cases and splenic artery ligation in 2 cases, the calibers of hepatic artery enlarged significantly and ensuing improved arterial supply of the liver.Conclusion The combination of splenic artery occlusion and splenic RFA can improves the safety and efficacy for the management of severe hypersplenism due to liver cirrhosis and portal hypertension, and can correct splenic artery steal syndrome and ameliorate the hepatocellular function.关键词
脾功能亢进/高血压,门静脉/导管消融术/脾动脉分类
医药卫生引用本文复制引用
刘全达,周宁新,宋扬,许小亚,段伟宏,孙梯业,晋志涛..脾动脉阻断技术在射频消融治疗门脉高压性脾功能亢进症中的应用[J].临床肝胆病杂志,2011,27(2):136-139,4.基金项目
中国博士后科学基金(20080441275) （20080441275）
北京市首都临床特色医学发展项目(2010) （2010）
