无机材料学报2011，Vol.26Issue(1)：17-21,5.DOI:10.3724/SP.J.1077.2011.00017
具有良好贯通性的颗粒造孔支架的制备及表征
Preparation and Characterization of Porous Scaffolds with Favourable Interpore Connectivity
摘要
Abstract
The pore interconnectivity is a key factor for the application of porous bioceramics as bone tissue engineering scaffolds. Packed wax spheres were treated with dimethyl benzene and acted as the porogen for the preparation of porous ceramic scaffolds, in order to increase the inter-sphere connectivity. The morphology, porosity,shrinkage, and the compressive strength of the obtained ceramic scaffolds were analyzed. The cell compatibility of the scaffolds was evaluated with Sprague-Dawley (SD) osteoblasts. The results showed that the pore interconnectivity and volumetric porosity were significantly increased by the dimethyl benzene treatment. Scaffolds with different porosities had similar shrinkage. Osteoblasts migrated deeply into the center of the porous ceramic scaffold through the interconnected pores and got normal activity. Porous scaffolds with better interpore connectivity could provid more space for the proliferation of osteoblasts.关键词
多孔支架/颗粒造孔/贯通性/桥联结构分类
医药卫生引用本文复制引用
郭来阳,张靖微,赵婧,汪建新,翁杰,张聪..具有良好贯通性的颗粒造孔支架的制备及表征[J].无机材料学报,2011,26(1):17-21,5.基金项目
国家自然科学基金重点项目(30870630) （30870630）
教育部高等学校博士学科专项科研基金(20070613062) （20070613062）
四川省科技计划项目(2008Jy0062) （2008Jy0062）
