中国病理生理杂志2011，Vol.27Issue(1)：204-208,5.DOI:10.3969/j.issn.1000-4718.2011.01.041
合成红藻氨酸诱发大鼠癫痫作用的研究
Synthetic kainate acid induces seizures in rats
许华 1张洁 2喻静3
作者信息
- 1. 暨南大学药学院,广东,广州,510632
- 2. 太原市妇幼保健院药剂科,山西,太原,030012
- 3. 广州市质量监督检测研究院,广东,广州,510110
- 折叠
摘要
Abstract
AIM : To observe the effect of synthetical kainic acid ( SKA ) on inducing epileptic seizure in rats.METHODS : Forty Wistar rats were divided into normal control group, 5 mg/kg, 10 mg/kg and 12 mg/kg SKA - treated groups and kainic acid ( KA ) positive control group.The SKA was injected intraperitoneally.The changes of the epileptic behaviors were observed for 8 h successively and the electroencephalography was recorded for 3.5 h.RESULTS : SKA induced epileptic seizures at the dose of 5 - 12 mg/kg by intraperitoneal injection.No apparently difference between SKA and KA on the changes of epileptic hehaviors or electroencephalography was observed.However, the epileptic seizure induced by SKA showed obvious stages, regular pattern and action steady.In addition, SKA caused lower fatality than KA did.CONCLUSION: SKA induces epileptic seizure in rats and the dose of 10 mg/kg hy intraperitoneal injection is the optimal.关键词
合成红藻氨酸/模型,癫痫分类
医药卫生引用本文复制引用
许华,张洁,喻静..合成红藻氨酸诱发大鼠癫痫作用的研究[J].中国病理生理杂志,2011,27(1):204-208,5.
