陕西医学杂志2011，Vol.40Issue(2)：138-140,156,4.
绒毛组织mTNFR1的表达与不明原因早期自然流产的关系
The relationship between unexplained early spontaneous abortion and the expression of membrane tumor necrosis factor receptor 1 protein in chorionic villi
摘要
Abstract
Objection: To investigated the relationship between unexplained early spontaneous abortion and the expression of membrane tumor necrosis factor receptor 1 protein in chorionic villi. Methods :Thirty-one women, who had unexplained spontaneous abortion at 6-10 weeks of gestational period ,were used as abortion group. The control group consisted of 30 normal pregnancy women who preferred artificial abortion at 6-10 weeks gestational period as well. Chorionic villous samples from the two groups were obtained at the time of abortion. Immunohistochemistry were used to determine the location and intensity of mTNFR1 in all the chorionic villous. Results: The expressive rate of mTNFR1 in villous stromal cells, vessel endothelial,cytotrophoblast and syncytiotrophoblast cells of abortion group were 100. 0 ％ (31/31) 、80. 7 ％ (25/31) 、100. 0％ (31/31)and 90. 3％ ( 28/31)respectively, and the control group were 75. 0 ％ (18/24)、 58. 3％ (14/24)、 100. 0％ (30/30)and 95. 8％(23/24)respectively. The expressive rate of mTNFR1 in villous stromal cells from the abortion group was higher than that in control group(100. 0％ vs 75. 0％,P＜0. 01). Whereas, there were no signification difference of mTNFR1 expressive rate in vessel endothelial, cytotrophoblast and syncytiotrophoblast cells between the two groups ( P＞ 0. 05) , immunohistochemistry results also reveal that the intensity of mTNFR1 expression in villous stromal cells from the abortion group were stronger than that in control group ((P＜0. 01). Conclusion: The over expressing mTNFR1 in villous stromal cells, can possibly cause pathological changes or tissue damage , destruct immune balance of maternal-fetal interfaces in chorionic villi stormal locally, may responsible for unexplained early spontaneous abortion spontaneous abortion.关键词
流产/细胞因子/免疫组织化学/妊娠分类
医药卫生引用本文复制引用
闫春芳,马瑞霞,王立琴,于学文..绒毛组织mTNFR1的表达与不明原因早期自然流产的关系[J].陕西医学杂志,2011,40(2):138-140,156,4.基金项目
陕西省卫生厅资助项目(编号060021) （编号060021）
