浙江医学2011，Vol.33Issue(2)：186-189,4.
含益生菌序贯疗法作为根除幽门螺杆菌二线疗法的临床观察
Probiotics sequential therapy as the second-line regimen in Helicobacter pylori eradication
胡桂梅 1王伯军1
作者信息
- 1. 315020,宁波大学医学院附属医院消化科
- 折叠
摘要
Abstract
Objective To compare the efficacy and side effects of probiotics sequential therapy with traditional quadruple regimen therapy after failed first- line triple regimen therapy. Methods Eighty six peptic ulcer patients were allocated randomly into two groups: Group A received traditinal quadruple regimen therapy for two weeks; Group B received traditional quadruple regimen therapy for one week after two weeks ofbifid- triple viable powder 630mg rid; all ended with four weeks of esomepreazole magnesium enteric- coated tablets 20mg qd. Helicobacter pylori eradication rates, incidence rates of side effect, the quality of peptic ulcer healing and gastric mucosa inflammation of both groups were assessed. Results There was no difference in Helicobacter pylori eradication rates by intention- to- treat and pre- protocol analysis between groups A and B; while incidence rates of side effect were 31.0％ in group Aand 12.0％ in group B respectively (P＜0.05); the quality ofpeptic ulcer healing in group B was higher than that in group A (75.6％ vs 52.4％, P＜0.05). Gastric mucosa inflammation was improved after treatment in both groups, but g group B was better than group A, especially in patients with Helicobacter pylori eradication. Conclusion Compared with traditional quadruple regimen therapy, probiotics sequential therapy can reduce side effect, improve the quality of peptic ulcer healing and ameliorate gastric mucosa inflammation.关键词
幽门螺杆菌/益生菌/根除/不良反应/愈合质量引用本文复制引用
胡桂梅,王伯军..含益生菌序贯疗法作为根除幽门螺杆菌二线疗法的临床观察[J].浙江医学,2011,33(2):186-189,4.
