中国组织工程研究与临床康复2011，Vol.15Issue(5)：932-935,4.DOI:10.3969/j.issn.1673-8225.2011.05.042
无血缘夫妻活体供肾7例肾移植
Unrelated spouse living donor kidney transplantation in 7 cases
摘要
Abstract
BACKGROUND: It is a hot research point that immune tolerance to facilitate long-term survival in organ transplantations produced by induction for transplant recipients-receptor chimera receptor, and a number of successful experience and knowledge has been obtained in experimental animal models. The clinical practice also showed that the compared with other relatives, the rejection of husband-wife after organ transplantation is smaller.OBJECTIVE: To investigate clinical effects of unrelated living donor kidney transplantation (husband to his wife).METHODS: A retrospective analysis of 7 recipients receiving spousal renal donor transplantation was performed. The ages of donors were 32-58 years old, and the recipients were 31-56 years old. The marriage age was 5-36 years. Four of them had completely identical ABO blood group, 1 case with O-B, 1 case with O-A, and 1 case with A-AB. The lymphocytotoxic cross match test was negative. One antigen mismatch in 1 case, two antigen mismatch in 2 cases, three antigen mismatch in 3 cases, and four antigen mismatch in 1 case. They underwent open approach nephrectomy, left kidney in 6 cases, and 1 case of right kidney. The triple immunosuppressive regimen (cyclosporine A/tacrolimus + mycophenolate mofetil + prednisone) was used to prevent rejection. All recipients and donors were followed up for 3-70 months.RESULTS AND CONCLUSION : All operations achieved totally success. None suffered surgical complications. The donors experienced a transient rise in serum, blood pressure, urine and renal functions of the donor were normal, recepients/allografts were all survived. Although preoperative tissue typing results were poor, the spouse's long-term living together leads to the immune tolerance, so the rates of renal allograft rejection were lower, the results were satisfactory. Spouse transplantation had more advantages than of other relatives.关键词
活体供肾/肾移植/夫妻/移植/器官移植分类
医药卫生引用本文复制引用
曲青山,郭娟,苗书斋,刘旭华,邢利,张彦选..无血缘夫妻活体供肾7例肾移植[J].中国组织工程研究与临床康复,2011,15(5):932-935,4.基金项目
郑州市科技攻关计划项目(郑科计(2008)8号),妻子对丈夫免疫耐受的临床研究. （郑科计(2008）
