中国药理学通报2011，Vol.27Issue(3)：325-328,4.
愤怒、郁怒反应模型大鼠海马5-HTR2C的基因表达
The expression of 5-HTR2C in the hippocampal of the anger-in and anger-out animal model
摘要
Abstract
Aim Anger is an important emotion response affecting human health, which is divided into anger-in and anger-out.But the mechanism of disease and syndrome induced both anger-in and anger-out is not yet fully clear.So the aim of the paper is to explore micro-mechanism of disease and syndrome induced both anger-in and anger-out.Methods The anger-in and anger-out animal models were prepared using a social isolation plus resident-intruder stress.The rats were treated by" tiao gan fang yao"Jingqianping granule and Jingqianshu granule.Normal rats as control.Genes closely related with anger-in and anger-out were initially screened utilizing Gene chip to detect hippocampus of other groups.The genes were 5-HTR2C, GABABR2 and 5-HTR3B.Futher 5-HTR2C in hippocampus moving was detected by RT-PCR and Western blot in the paper.Results Compared with normal group, the expressions of 5-HTR2C mRNA and protein of both anger-in and anger-out animal model were significantly higher in hippocampal( P ＜ 0.01 ).Meanwhile, the change of anger-out animal model group was more significant than that of anger-in animal model group.These changes were improved to normal levels in different degrees after administrating drugs.Conclusions The emotion responses of anger-in/anger-out can lead to changes of gene expression of 5-HTR2C in the hippocampal.In addition, to some extent." tiao gan fang yao can improve the above.The results illustrate the close relationship between 5-HTR2C and anger, closer with anger-out.These results provide direction and clues for further research.关键词
愤怒/郁怒/大鼠/RT-PCR/Western blot/5-HTR2C分类
医药卫生引用本文复制引用
王杰琼,张惠云..愤怒、郁怒反应模型大鼠海马5-HTR2C的基因表达[J].中国药理学通报,2011,27(3):325-328,4.基金项目
国家自然科学基金重点项目(No 30930110,30973688) （No 30930110,30973688）
