天然产物研究与开发2011，Vol.23Issue(1)：54-58,68,6.
胶原蛋白肽对高脂日粮小鼠抗氧化能力和血脂代谢的影响
Effects of Collagen Peptides on Antioxidant Capacity and Serum Lipid Metabolism of Mice Fed with High-fat Diet
摘要
Abstract
The effects of collagen peptides on antioxidant capacity and serum lipid metabolism of mice fed with high-fat diet were studied in the present work.Forty mice were randomly divided into 5 groups.They were fed with ordinary diet,high-fat diet,and high-fat diet with 0.5％ collagen peptides,1％ collagen peptides,and 0.1％ lipoic acid,respectively.The level of reactive oxygen species (ROS) ,contents of malondialdehyde (MDA) and antioxidant enzymes activities in blood (serum) and tissues and serum lipid level were determined after 42 days.The results showed that both 0.5％ and 1％ collagen peptides could remarkably decrease the levels of ROS and the contents of MDA, enhance the antioxidant capacity of mice,as well as improve the level of serum lipid.The antioxidant capacity and serum lipid level could recover to normal level when 1％ collagen peptides was added to high-fat diet.However, there were no significant effects in 0.5％ collagen peptides group.These results indicated that the appropriate collagen peptides could effectively enhance antioxidant capacity, relieve oxidative stress caused by high-fat diet and improve serum lipid metabolism.关键词
胶原蛋白肽/硫辛酸/高脂日粮/氧化应激/抗氧化能力/血脂代谢Key words
collagen peptides (CP) /lipoic acid (LA) /high-fat diet/oxidative streas/antioxidant capacity/serum lipid metabolism分类
医药卫生引用本文复制引用
李亚欣,施用晖,王洁昀,林云鉴,乐国伟..胶原蛋白肽对高脂日粮小鼠抗氧化能力和血脂代谢的影响[J].天然产物研究与开发,2011,23(1):54-58,68,6.基金项目
十一五"863项目":蛋白质的定向酶解及生物活性肽富集纯化研究(2007AA0Z325) （2007AA0Z325）
国家科技支撑计划课题:抗氧化功能食品的研究与产业化(2006BAD27B06) （2006BAD27B06）
