中国实验动物学报2011，Vol.19Issue(1)：84-88,5.DOI:10.3969/j.issn.1005-4847.2011.01.019
喹啉酸所致亨廷顿病动物模型
Animal models of Huntington's disease induced by quinolinic acid
邢秋云 1李峰2
作者信息
- 1. 首都医科大学基础医学院,北京,100069
- 2. 首都医科大学北京神经科学研究所、北京市神经再生及修复研究重点实验室、教育部神经变性病学重点实验室,,北京,100069
- 折叠
摘要
Abstract
Huntington's disease (HD) is an autosomal dominant genetic disease characterized by dance-like involuntary movements and progressive cognitive impairment. Excitatory toxicity is recognized as one of the mechanisms of HD pathogenesis. Quinolinic acid (QA) is an excitotoxic drug, which can lead to brain dysfunction by killing the related neurons in the brain, and being a further mimic of changes in HD. This article presents the merits and drawbacks of animal HD models induced by QA as well as the current application of the models in studies of drugs and treatment of this disease.关键词
亨廷顿病/喹啉酸/模型,动物/应用分类
生物科学引用本文复制引用
邢秋云,李峰..喹啉酸所致亨廷顿病动物模型[J].中国实验动物学报,2011,19(1):84-88,5.
