山东医药2011，Vol.51Issue(9)：22-24,3.
抑郁症患者抗抑郁治疗前后认知功能变化及意义
Changes of attention and executive functions in depressive patients before and after treatment and its significance
摘要
Abstract
Objective To assessed the change of the performance of working memory, attention and executive functions in depressive patients before and after treatnent. Methods Fifty-five depressive patients (study group) and 55 healthy people ( control group) were enrolled. HAMD-24 was used to evaluate the severity of depression. Digit Span of WAIS-RC, CPT, strcop color word task and WCST were employed to assess working memory, attention and executive function. All of tests were evaluated before and after treatment in patients or in baseline and 6 weeks later in controls. Results The study group showed significantly lower scores in digits forward and backward and CPT (P ＜ 0.01 ), higher interference scores in Stroop task ( P ＜0.01 ), and more perseverative errors and non-parseverative errors ( P ＜0.01 ) in WCST than those of controls at baseline. After 6 weeks treatment, the performances of digits forward and backward, CPT, Stroop task and WCST had significantly improved in study group (P ＜0. O5 or ＜0.01), but there were significant difference between two groups in all tests ( P ＜0. O5 or ＜0.01 ). Conclusions Antidepressants treatment could improve working memory, attention and executive functions in patients. Depressive patients show persistent cognitive deficits after treatment.关键词
抑郁症/注意/执行功能/工作记忆/神经心理学评估分类
医药卫生引用本文复制引用
张迎黎,张红梅,孟焱,陈佐明..抑郁症患者抗抑郁治疗前后认知功能变化及意义[J].山东医药,2011,51(9):22-24,3.基金项目
河南省医学科技攻关计划项目(200903096). （200903096）
