临床误诊误治2011，Vol.24Issue(3)：35-37,3.
丁苯酞软胶囊治疗血管性痴呆精神心理量表评分的变化及临床疗效观察
Clinical Effect and Mechanism of Butyiphthalide Soft Capsules in Treatment of Vascular Dementia
卢海丽 1杨建芳 1梁桂琴 1朱荣彦 1侯永革 1张景瑞 1许月琨1
作者信息
- 1. 050011,石家庄,石家庄市中心医院神经内二科
- 折叠
摘要
Abstract
Objective To observe the effect and safety of Butyiphthalide Soft Capsules in treatment of vascular dementia ( VD), and to research the probable mechanisms.Methods 100 mild and moderate VD patients were randomly divided into Butylphthalide group and Nimodipine group.Both groups were treated for 3 months.Efficacy was assessed by MMSE, ADL and CDR scale 1 day before treatment and in the 2nd, 4th and 12th weeks after treatment.The improvement of symptom and safety of drug use were evaluated before and after treatment.Results There was significant difference of scale in both groups before and 12 weeks after treatment( P ＜0.05), and there was significant difference between the two groups( P ＜0.05 ); the total effect rate in Butylphthalide group was 84.9％ ,while 64.0％ in Nimodipine group, There was significant difference between the two groups( P ＜0.05 ), but the incidences of adverse events in the two groups showed no significant difference ( P ＞ 0.05).Conclusion Butylphthalide Soft Capsules is more effective in treating mild and moderate VD than Nimodipine, and is safe to clinical application.关键词
丁苯酞/尼莫地平/血管性痴呆/量表/疗效/机制探讨Key words
Butylphthalide/ Nimodipine/ Vascular dementia/ Rating scale/ Effect/ Mechanism investigation分类
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卢海丽,杨建芳,梁桂琴,朱荣彦,侯永革,张景瑞,许月琨..丁苯酞软胶囊治疗血管性痴呆精神心理量表评分的变化及临床疗效观察[J].临床误诊误治,2011,24(3):35-37,3.
