中国感染控制杂志2011，Vol.10Issue(1)：18-21,66,5.
甲乙煎对肝纤维化大鼠肝组织MMP2及TGFβ1表达的作用
The MMP2 and TGFβ1 expression changes of rat liver fibrosis tissue influenced by Jiayijian
摘要
Abstract
Objective To observe the effects of a traditional Chinese medicine Jiayijian on the matrix metalloproteinase-2 (MMP2) and transforming growth factor-beta1 (TGFβ1) expression in experimental hepatic fibrosis rats.Methods Sixty male Wister rats were randomly divided into normal control group and liver fibrosis model group.Dimethylnitrosamine(DMN) was administered to induce liver fibrosis in the model group, and rats in model group were randomly divided into model control group and Jiayijian treatment groups with high concentration (22g/[kg ·d])and low concentration (5. 5g/[kg · d]) 4 weeks after liver fibrosis had been induced. All rats were killed after 4 weeks intragastric administration of Jiayijian. The expression of MMP2 and TGFβ1 of rat liver tissue were detected by immunohistochemical method. Results The expression of TGFβ1 in high and low concentrations of Jiayijian treatment groups was significantly lower than that in the model control group (P＜0. 05), and the expression of TGFβ1 in the high concentration of Jiayijian treatment group was significantly lower than the low concentration of Jiayijian treatment group (P＜0. 05), but there was no significant difference in the expression of MMP2 between high and low concentrations of Jiayijian treatment groups and the model control group (P＞0. 05). Conclusion Jiayijian can down-regulate the expression of TGFβ1 of experimental hepatic fibrosis model rat's liver tissue, which is the one of the mechanisms of anti-liver-fibrosis.关键词
甲乙煎/肝纤维化/基质金属蛋白酶-2/转化生长因子1/大鼠/医学,中国传统/中药分类
医药卫生引用本文复制引用
王卫华,王兵亮,郭卫刚,柴广丽,贾世复..甲乙煎对肝纤维化大鼠肝组织MMP2及TGFβ1表达的作用[J].中国感染控制杂志,2011,10(1):18-21,66,5.基金项目
邯郸市科学技术研究与发展计划项目(0923108133) （0923108133）
