南方医科大学学报2011，Vol.31Issue(1)：93-95,3.
肿节风颗粒对小型猪腮腺放射损伤所致活性氧簇的清除作用
Scavenging effect of Sarcandra glabra powder on radiation-induced reactive oxygen species in the parotid gland of miniature pigs
摘要
Abstract
Objective To investigate the effect of Sarcandra glabra in scavenging reactive oxygen species (ROS) produced by y-ray irradiation in the parotid gland of miniature pigs. Methods Forty-five male miniature pigs were randomly divided into control group, radiation group and radiation plus medication group, and each group contained 3 parallel groups (subgroups a, b and c). From 1 week before exposure of the parotid gland region to 15 Gy γ-ray irradiation (which was not administered in the control group), the miniature pigs in radiation plus medication group were given Sarcandra glabra powder, while those in the other groups received an equal amount of saline. Bilateral parotid glands were taken and weighed on the days 10, 40 and 90 following the exposure in subgroups a, b, and c, respectively, and ROS content in the parotid glands were determined by enzyme-linked immunosorbent assay. Results The content of ROS was significantly lower in radiation plus medication group than in the radiation group (P< 0.01). In the radiation plus medication group, the ROS content showed no significant difference between subgroups a and b or between subgroups a and c (P>0.01), but differed significantly between subgroups b and c (P0.01). Sarcandra glabra showed a strong ROS-scavenging effect 10 days after the irradiation, and the ROS content was similar with that in the control group (P>0.01); at 40 and 90 days, the ROS-scavenging effect of Sarcandra glabra was still observable, but the ROS content was significantly higher in the irradiation plus medication group than in the control group (P<0.01). Conclusion Sarcandra glabra displays a ROS-scavenging effect in the parotid gland of miniature pigs against irradiation, especially at 10 days following the exposure, which may serve as the main mechanism for the protective effect of Sarcandra glabra against radiation injury in the parotid gland.关键词
肿节风/小型猪/腮腺/放射损伤/活性氧簇Key words
Sarcandra glabra/ miniature pigs/ parotid gland/ radiation injury/ reactive oxygen species分类
医药卫生引用本文复制引用
张海东,王仁生,马姗姗,梁菲菲,肖帅,黎国尖..肿节风颗粒对小型猪腮腺放射损伤所致活性氧簇的清除作用[J].南方医科大学学报,2011,31(1):93-95,3.基金项目
国家自然科学基金(30960103) （30960103）
