国际病理科学与临床杂志2011，Vol.31Issue(1)：81-86,6.DOI:10.3969/j.issn.1673-2588.2011.01.017
TGF-β诱导上皮间充质转化的信号通路研究
TGF-β signaling pathway in epithelial mesenchymal transition
吴腾云 1张威 1曹冬梅1
作者信息
- 1. 第二军医大学基础医学部病理生理学教研室,上海,200433
- 折叠
摘要
Abstract
During embryonic development and cancer metastasis or fibrosis, epithelial-mesenchymal transition (EMT) is a cellular process whereby epithelial cells disintegrate their intercellular contacts, organize their motility apparatus, and move to new locations. As a necessary inducer of EMT,transforming growth factor β (TGF-β) promotes and regulates EMT through Smad signaling-dependent or independent pathways, such as Erk, PI3K/Akt, JNK/p38, WNT/GSK3/β, catenin, etc. This article reviewed the molecular mechanisms of TGF-β signaling pathways in EMT.关键词
转化生长因子β/上皮间充质转化/信号转导Key words
transforming growth factor β/ epithelial-mesenchymal transition/ signaling transduction引用本文复制引用
吴腾云,张威,曹冬梅..TGF-β诱导上皮间充质转化的信号通路研究 [J].国际病理科学与临床杂志,2011,31(1):81-86,6.
