中国神经再生研究（英文版）2011，Vol.6Issue(1)：6-11,6.DOI:10.3969/j.issn.1673-5374.2011.01.001
Transplantation of X-box-binding protein-1 gene-modified neural stem cells in the lateral ventricle of brain ischemia rats
Transplantation of X-box-binding protein-1 gene-modified neural stem cells in the lateral ventricle of brain ischemia rats
Yao Wang 1Xiaokun Gang 2Qun Liu 1Lei Song 1Lina Lin 1Jia Fan3
作者信息
- 1. Department of Neurology,First Hospital,Jilin University,Changchun 130021,Jilin Province,China
- 2. Department of Endocrinology,First Hospital,Jilin University,Changchun 130021,Jilin Province,China
- 3. Department of Neurology,Second Hospital,Jilin University,Changchun 130041,Jilin Province,China
- 折叠
摘要
Abstract
X-box-binding protein-1 (XBP-1) is an essential transcription factor in endoplasmic reticulum stress.In this study,XBP-1 gene-transfected neural stem cells (NSCs) were transplanted into lesion sites to ensure stability and persistent expression of XBP-1,resulting in the exertion of anti-apoptotic effects.Simultaneously,XBP-1 gene transfection promotes the survival and differentiation of transplanted NSCs.Results from this study demonstrated that survival,proliferation and differentiation of XBP-1 gene-modified NSCs were enhanced when compared to unmodified NSCs at 28 days post-transplantation (P ＜ 0.05).A diminished number of apoptotic neural cells increased Bcl-2 expression and reduced Bax expression,and were observed in the ischemic region of the XBP-1-NSCs group (P ＜ 0.05).These results indicated that modification of the XBP-1 gene enhances the survival and migration of NSCs in vivo and decreases the occurrence of apoptosis.关键词
X-box-binding protein-1/neural stem cells/transplantation/brain ischemia/brain injury/neural regenerationKey words
X-box-binding protein-1/neural stem cells/transplantation/brain ischemia/brain injury/neural regeneration引用本文复制引用
Yao Wang,Xiaokun Gang,Qun Liu,Lei Song,Lina Lin,Jia Fan..Transplantation of X-box-binding protein-1 gene-modified neural stem cells in the lateral ventricle of brain ischemia rats[J].中国神经再生研究（英文版）,2011,6(1):6-11,6.
