中国药房2011，Vol.22Issue(5)：387-389,3.
鞘内注射和侧脑室注射七氟烷对小鼠抓力的影响研究
Effect of Sevoflurane on the Grip Strength of Mice by Intrathecal and Intracerebroventricular Injection
摘要
Abstract
OBJECTIVE: To study the main site of muscle-relaxation induced by sevoflurane (Sev). METHODS: 64 mice were randomly divided into intrathecal injection (it) group and intracerebroventricular injection (icv) group. Then it group and icv group were redivided into aCSF group (0.25 μL·g-1), Sev1 group (0.25 mg·g-1), Sev2 group (0.31 mg·g-1), Sev3 group (0.39 mg·g-1) with each group of 8 mice. The duration of injection was 10 s and acupuncture manipulation time lasted for 15 s. The grip strength of mice were recorded before administration and 5, 10, 15, 20, 25, 30 min after administration. RESULTS: Compared with aCSF group, the grip strength of mice in each group had reduced as the concentration of Sev increased, there was significant difference between Sev2 group and Sev3 group (P＜0.05 or P＜0.01 ). Compared with icv groups, the grip strength of mice in Sev2 group and Sev3 group of it group had reduced (P＜0.01). CONCLUSION: Intratheeal and intracerebroventricular injection of sevoflurane produce muscle relaxation effect in dose-dependent manner, especially in it group. It can be concluded that spinal cord is the main site of muscle-relaxation induced by sevoflurane.关键词
七氟烷/肌松作用部位/鞘内注射/侧脑室注射/小鼠/抓力分类
医药卫生引用本文复制引用
周美艳,张明阳,刘亚君,戴体俊..鞘内注射和侧脑室注射七氟烷对小鼠抓力的影响研究[J].中国药房,2011,22(5):387-389,3.基金项目
国家自然科学基金资助项目(30872432、30471657、39970715) （30872432、30471657、39970715）
江苏省自然科学基金资助项目(BK2001143) （BK2001143）
