实用肝脏病杂志2011，Vol.14Issue(2)：116-118,3.DOI:10.3969/j.issn.1672-5069.2011.02.012
慢加急性乙型肝炎肝衰竭患者肝组织IFN-γ、TNF-α和IL-10的表达
Imbalanced intrahepatic expression of interferon gamma,tumor necrosis factor alpha,and interleukin-10 in hepatitis B virus infection patients with acute-on-chronic liver failure
摘要
Abstract
Objectives This study attempted to determine intrahepatic expressions of proinflammatory and anti-inflammatory cytokines in patients with acute-on-chronic liver failure (ACLF)arosing from HBV infection. Methods In situ expressions of interferon(IFN- γ ) , tumor necrosis factor( TNF- α )and interleukin 10 ( IL-10 )were analyzed in the livers of patients with ACLF,chronic hepatitis B (CHB),and normal controls (NC)by using immunohistochemistry. Results Intrahepatic IFN- γ and TNF- α expressions were markedly up-regulated in patients with ACLF as compared to CHB and NC(both P＜0.001);However,similar IL-10 expressions were ohserved in ACLF and CHB;IFN -γ over-expression was actively correlated with expression of TNF-α (r=0.886,P＜0.001).Conclusions The imbalanced expression of proinflammatory and anti-inflammatory cytokines may contribute to immuno-pathogenesis in HBV-infected ACLF.关键词
慢加急性肝衰竭/IFN-γ/TNF-α/IL-10/免疫组化引用本文复制引用
田辉,孙颖,滕光菊,赵军,常彬霞,张伟,李保森,邹正升..慢加急性乙型肝炎肝衰竭患者肝组织IFN-γ、TNF-α和IL-10的表达[J].实用肝脏病杂志,2011,14(2):116-118,3.基金项目
国家自然科学基金资助项目(编号:81072424) （编号:81072424）
