中山大学学报（自然科学版）2011，Vol.50Issue(1)：70-74,5.
毛冬青中三萜皂苷类化合物的分离(Ⅲ)
Triterpene Saponins Isolated from Ilex pubescens(Ⅲ)
摘要
Abstract
Traditional chinese medicine of Ilex pubescens ( Mao - Dong - Qing) is commonly used to treat the cardiovascular diseases in South China. The preliminary bioassays showed that the total saponins isolated from Ilex pubescens exhibited significant potent degrading the plasma viscosity in rats. Meanwhile,our recent works indicated that the n - BuOH soluble fractions of ethanol extract (70％) from the root of the same species obviously inhibited the contraction (60 μg/mL) of rabbit thoracic aorta induced by norpinephrine in vitro. As a continuation of bioactive constituent from the n - BuOH of Ilex pubescens, five triterpene saponins were isolated. Their structures were elucidated by chemical, physical methods and spectroscopic analysis methods. As a result, they were identified as mussaendoside R ( 1 ), ziyu - glycoide I (2), Lucyoside H (3), ilexoside A (4), ilexoside O (5), excepescially. Compounds 1, 2 and 3 were firstly obtained from Ilex pubescens.关键词
毛冬青/三萜皂苷类化合物/结构研究分类
化学化工引用本文复制引用
张翠仙,林朝展,杨金燕,熊天琴,邓洁薇,韦踽龙,赵钟祥,祝晨蔯..毛冬青中三萜皂苷类化合物的分离(Ⅲ)[J].中山大学学报（自然科学版）,2011,50(1):70-74,5.基金项目
高等学校博士学科点专项科研基金联合资助项目(20094425110008) （20094425110008）
广东省科技厅国际合作资助项目(2008A050200005) （2008A050200005）
广东省中医药管理局基金资助项目(2007336) （2007336）
广州中医药大学创新基金资助项目(2007C016,09CX015) （2007C016,09CX015）
国家中医药管理局重大科技专项(中药质量研究专论)资助项目(国中医药科2001ZDZX005) （中药质量研究专论）
