中国全科医学2011，Vol.14Issue(12)：1296-1299,4.
衡阳地区溶质载体家族30成员8基因单核苷酸多态性与2型糖尿病的相关性研究
The Relationship between Polymorphisms of Solute Carrier Family30,Member8 Gene and Type 2 Diabetes
摘要
Abstract
Objective To explore the relationship between the polymorphism of rs13266634C/T of SLC30A8 gene and T2DM and IGR in Hengyang region. Methods SLC30A8 gene rs13266634 polymorphisms of 236 T2DM patients, 120 IGR patients and 218 NGT were tested by PCR - RFLP. HOMA - β and HOMA - lR were used to evaluate β - cell function and insulin resistance. Results In T2DM and IGR group , the frequencies of C allele and CC genotype of rs13266634C/T were significantly higher than those in NGT group ( P ＜ 0. 01 ). The C allele of rs13266634C/T significantly increased T2DM and IGR risk with an allelic odd ratio ( OR ) of 1. 89 and 1. 57. than those who had T allele. HOMA - β level of the patients with CC gentype was significantly lower than those with CT and TT genotype in IGR group ( P ＜ 0. 01 ). Conclusion ( 1 ) SLC30A8 rs13266634C/T genetic polymorphism is associated with T2DM and IGR. C allele is probahly the risk gene of T2DM. ( 2 ) SLC30A8 gene may increase the liability of T2DM by affecting the function of islet beta cell.关键词
SLC30A8基因/多态性,单核苷酸/糖尿病,2型/糖调节受损分类
医药卫生引用本文复制引用
王建平,李晶,邓珊珊..衡阳地区溶质载体家族30成员8基因单核苷酸多态性与2型糖尿病的相关性研究[J].中国全科医学,2011,14(12):1296-1299,4.基金项目
湖南省教育厅项目(09C844) （09C844）
